Phyllodes tumors of the breast are rare tumors that start in the connective stromal. Total score ranges from 0 to 3,600 being 0 the worst and 3,600 the best. A 40 yearold white woman presented with threeweek history of pain and functional impairment of the left lower limb. A phyllodes tumor, which derives from the greek word phullon or leaf, is a rare breast tumor usually effecting premenopausal women in their 40s. They are graded as benign, borderline or malignant based on the world health organisation who classification, according to a constellation. A phyllodes tumor of the breast is a rare fibroepithelial tumor, accounting for 0. Incisional biopsy showed malignant pt with heterologous highgrade angiosarcoma. Benign and borderline tumors are rare tumor types that have a positive outlook and high survival rate, while the risk of. While managing a giant phyllodes tumor, emphasis should be on complete extirpation of all visible tumors and breast tissue during mastectomy to minimize the chances of recurrence. Phyllodes tumor are divided into benign, borderline and malignant histologic categories. Request pdf tumor phyllodes phyllodes tumors is a rare fibroepithelial neoplasm. Phyllodes tumors are rare fibroepithelial neoplasms that account for 0. It is difficult to genralize about the behavior of phyllodes breast tumors. Focal fibroadenomatous and fibrocystic changes are observed.
Phyllodes tumor is an extremely rare tumor of the breast. Phyllodes tumor, also known as cystosarcoma phyllodes, is a rare fibroepithelial tumor of the breast which has some resemblance to a fibroadenoma. Malignant phyllodes tumor of breast is a rare tumor of the breast, which is observed in middleaged individuals mostly women. Aggressive malignant phyllodes tumor sciencedirect. Distant metastases in phyllodes tumours of the breast.
Assessment of patients begins with the clinical examination, because phyllodes tumor often presents as a large tumor measuring greater than 4 cm in maximum diameter. Phyllodes tumor pt of the breast can be categorized into benign, borderline and malignant subgroups depending on various histopathological factors. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. We present a case of a 33yearold woman affected by. Its numbers are much fewer than breast carcinomas, with a proportion of only 1. Current trends in the management of phyllodes tumors of. Statistics of phyllodes tumor 39 people with phyllodes tumor have taken the sf36 survey.
Phyllodes tumors of the breast are rare fibroepithelial lesions that comprise less than 1% of all breast malignancies. Lymph node involvement is rarely described in phyllodes tumors. Chest computed tomography and magnetic resonance imaging showed a doubling in mass size, with pectoralis major muscle involvement. Only a few cases of malignant phyllodes tumors metastatic to bone have been reported. Phyllodes tumor bears specific clinical characteristic and can be considered as a differential diagnosis for the breast lumps. Generally, phyllodes tumor presents as a rapidly growing and clinically benign breast lump in females within the fourth or fifth decade of life. Phyllodes tumor of the breast genetic and rare diseases. Malignant phyllodes tumor of the breast with heterologous. Phyllodes tumours pts of the breast are uncommon fibroepithelial neoplasms, comprising 0. Malignant and borderline phyllodes tumor of breast treated.
In most series, all phyllodes tumors may recur, but only the borderline and malignant phyllodes tumors metastasize. Phyllodes tumors of the breast can be benign, malignant, or borderline. Biphasic tumor resembling fibroadenoma but with hypercellular mesenchymal component organized in leaflike pattern around benign epithelial myoepithelial lined spaces. Depending on the size of the breast and the location of the phyllodes tumor, mastectomy may also be required for tumors that are between 5 and 10 cm in diameter. They account for less than 1% of all breast neoplasms. A rare case of breast malignant phyllodes tumor with. Bone metastasis from malignant phyllodes breast tumor. Phyllodes also spelled phylloides tumors are rare breast tumors that, like fibroadenomas, contain 2. From clinical point of view, phyllodes tumors pt can mimic a breast carcinoma. Phyllodes tumors can either be benign, suspicious of malignancy or overtly malignant. Phyllodes tumor benign or malignant, phylloides tumor, phyllodes tumour, phylloides tumour, mullers tumor, cystosarcoma phyllodes, phyllodes, pt, and csp.
Traditionally, phyllodes tumors are graded by the use of a set of histologic data into benign, borderline, and malignant. Ki67 labeling index revealed positivity in about 10% of stromal cells, thus the case is consistent with phyllodes tumor. A coreneedle biopsy revealed hyalinized fibroadenoma. Ppt phyllodes breast tumor powerpoint presentation. Informatie over download hier informatie over phyllodes tumoren in samenwerking met avl amsterdam. The preoperative diagnosis and proper management are crucial in phyllodes tumor because of their tendency to recur and malignant potential in some of these tumors. For language access assistance, contact the ncats public information officer. Phyllodes tumors are rare fibroepithelial tumors accounting for less than 1 % of all breast neoplasms. It is typically a large, fast growing mass that forms from the periductal stroma of the breast. The difficulty in distinguishing between phyllodes tumors and benign fibroadenoma may lead to misdiagnosis. And it is characterized by expanded stroma with increased cellularity and elongated epitheliumlined clefts. Who classifies tumors into benign, borderline and malignant and it is the best methods to predict the local recurrence, distant metastasis or bath after resection. No evidence of tumor necrosis, cytologic atypia, invasive margin, heteroglous elements. Phyllodes tumors of the breast final free download as powerpoint presentation.
Phyllodes tumor of breast could be either benign or malignant variety and they can grow into very large sizes and distort the breast. Phyllodes tumor having a benign histologic appearance rarely metastasizes but can recur, whereas approximately 12% of malignant phyllodes tumors metastasize. This includes the tissue and ligaments that surround the ducts. My slides were sent to mayo for a confirming second pathology, and they agreed with the original pathologist. Phyllodes breast tumor joint hospital surgical grand round 26 april 2014 ng yuen shan, sandy tuen mun hospital triple assessment, in patients with phyllodes tumors.
Phyllodes tumors grow in the connective tissue of the breast, called the stroma. Mammary carcinomas within phyllodes tumors have been rarely reported. Phyllodes tumor page 1 of 4 md anderson cancer center. However, in the setting where additional recurrence would create significant. Highgrade phyllodes tumor is a rare but aggressive breast malignancy and forms approximately 25% of all phyllodes tumors. Phyllodes tumor represents one of the fibroepithelial breast neoplasms that accounts for 0. The 5 year disease free survival was 81% and time to. Download a printable pdf of this information about borderline and malignant phyllodes tumours 1.
Indeed, the diagnosis will depend upon the specific histological findings in. To describe a case series of patients with phyllodes tumor diagnosis. A free powerpoint ppt presentation displayed as a flash slide show on id. I had an excisional biopsy that was diagnosed as a poorly differentiated, high grade, malignant phyllodes tumor. Although malignant pts may be indolent and controlled by local excision, they frequently show local and. In contrast to other fibroadenomas, the phyllodes breast tumor has the potential to. This information is about borderline and malignant phyllodes tumours. In addition to stromal overgrowth and hypercellularity, malignant phyllodes tumors are characterized by infiltrative margins, atypical mitoses, necrosis, hemorrhage, and atypia. The term cystosarcoma phyllodes was coined by johannes muller in 1838 to describe the gross appearance of this cystic, fleshy, leafy, tumor of the breast, which he clearly stated to be a benign tumor. If you have problems viewing pdf files, download the latest version of adobe reader. It occurs in females in the third and fourth decades.
Phyllodes tumors are often large, bulky, fast growing masses that form from the intralobular stroma of the breast. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 toll free. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. What is a borderline or malignant phyllodes tumour. Benign phyllodes tumors can occur at any age, with patients on average in their. A second pathology check is always wise with rare tumors. Phyllodes tumors of the breast are uncommon fibroepithelial neoplasms, typified by hypercellular stroma and elongated ducts with irregular leaflike patterns due to stromal proliferation. Download hier informatie over phyllodes tumoren in. Originally described in 1838 by muller, phyllodes tumor is a rare fibroepithelial neoplasm which represents roughly 0. Please use one of the following formats to cite this article in your essay, paper or report. Phyllodes tumor is an uncommon biphasic breast tumor, with the ability to recur and metastasize, and it behaves biologically like a stromal neoplasm. The phyllodes breast tumor is a special kind of fibroadenoma that constitutes 0. Malignant phyllodes tumor represent anywhere from 1030% of all phyllodes tumors.
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